There are currently two vaccines used to treat monkeypox: JYNNEOS and ACAM2000.

The U.S. Department of Health and Human Services’ Administration for Strategic Preparedness and Response (ASPR) has begun distribution of the JYNNEOS vaccine to jurisdictions to support local monkeypox response efforts. Although there is currently a limited supply of the vaccine in the United States, more is expected in the coming weeks and months.

The City of Atlanta does not have our own allotment of monkeypox vaccinations. For more information on how to schedule a vaccination appointment visit Vaccinations page.


  • 2 dose vaccine given 28 days apart
  • People are considered to reach maximal immunity 14 days after the second dose
  • Most common side effects include:
    • Pain, redness, swelling, itching and firmness at the injections site
    • Muscle pain
    • Headache
    • Fatigue
  • Not known to cause significant side effects
  • FDA-licensed vaccine indicated for prevention of smallpox and monkeypox


  • 1 dose vaccine
  • People are considered to reach maximal immunity 4 weeks after receiving vaccine
  • Most common side effects include itching, sore arm, fever, headache, body ache, mild rash, fatigue
  • May cause myocarditis and pericarditis
  • Causes skin lesion that can spread infection to others
  • Should not be given to people who are immunocompromised or with underlying heart disease

*The CDC will continue to collect data on any side effects to better understand the protective benefits of these vaccines in the current outbreak.

*ACAM2000 is not currently in distribution for this outbreak.

Translate »